WALKING PATTERNS IN PARKINSON'S DISEASE WITH AND WITHOUT FREEZING OF GAIT
Identifieur interne : 001794 ( Main/Exploration ); précédent : 001793; suivant : 001795WALKING PATTERNS IN PARKINSON'S DISEASE WITH AND WITHOUT FREEZING OF GAIT
Auteurs : W. Nanhoe-Mahabier [Pays-Bas] ; A. H. Snijders [Pays-Bas] ; A. Delval [Pays-Bas, France] ; V. Weerdesteyn [Pays-Bas] ; J. Duysens [Belgique] ; S. Overeem [Pays-Bas] ; B. R. Bloem [Pays-Bas]Source :
- Neuroscience [ 0306-4522 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
The pathophysiology underlying freezing of gait (FOG) in Parkinson's disease remains incompletely understood. Patients with FOG ("freezers") have a higher temporal variability and asymmetry of strides compared to patients without FOG ("non-freezers"). We aimed to extend this view, by assessing spatial variability and asymmetry of steps and interlimb coordination between the upper and lower limbs during gait. Twelve freezers, 15 non-freezers, and 15 age-matched controls were instructed to walk overground and on a treadmill. Kinematic data were recorded with a motion analysis system. Both freezers and non-freezers showed an increased spatial variability of leg movements compared to controls. In addition, both patient groups had a deficit in interlimb coordination, not only between ipsilateral arms and legs, but also between diagonally positioned limbs. The only difference between freezers and non-freezers was a decreased step length during treadmill walking. We conclude that parkinsonian gait-regardless of FOG-is irregular, not only in the legs, but also with respect to interlimb coordination between the arms and legs. FOG is reflected by abnormal treadmill walking, presumably because this provides a greater challenge to the defective supraspinal control than overqround walking, hampering the ability of freezers to increase their stride length when necessary.
Affiliations:
- Belgique, France, Pays-Bas
- Gueldre, Hauts-de-France, Nord-Pas-de-Calais, Province du Brabant flamand, Région flamande
- Lille, Louvain, Nimègue
- Katholieke Universiteit Leuven
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Le document en format XML
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Nanhoe-Mahabier</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Snijders, A H" sort="Snijders, A H" uniqKey="Snijders A" first="A. H." last="Snijders">A. H. Snijders</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Delval, A" sort="Delval, A" uniqKey="Delval A" first="A." last="Delval">A. Delval</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neurology and Movement Disorders, Salengro Hospital, Lille Regional University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Weerdesteyn, V" sort="Weerdesteyn, V" uniqKey="Weerdesteyn V" first="V." last="Weerdesteyn">V. Weerdesteyn</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Rehabilitation, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Duysens, J" sort="Duysens, J" uniqKey="Duysens J" first="J." last="Duysens">J. Duysens</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Biomedical Kinesiology, Research Centre for Movement Control and Neuroplasticity, Katholieke Universiteit Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>5 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Louvain</settlement><region>Région flamande</region><region type="district" nuts="2">Province du Brabant flamand</region></placeName><orgName type="university">Katholieke Universiteit Leuven</orgName></affiliation></author><author><name sortKey="Overeem, S" sort="Overeem, S" uniqKey="Overeem S" first="S." last="Overeem">S. Overeem</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Bloem, B R" sort="Bloem, B R" uniqKey="Bloem B" first="B. R." last="Bloem">B. R. Bloem</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Central pattern generator</term><term>Parkinson disease</term><term>Walking</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Marche à pied</term><term>Maladie de Parkinson</term><term>Générateur central pattern</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathophysiology underlying freezing of gait (FOG) in Parkinson's disease remains incompletely understood. Patients with FOG ("freezers") have a higher temporal variability and asymmetry of strides compared to patients without FOG ("non-freezers"). We aimed to extend this view, by assessing spatial variability and asymmetry of steps and interlimb coordination between the upper and lower limbs during gait. Twelve freezers, 15 non-freezers, and 15 age-matched controls were instructed to walk overground and on a treadmill. Kinematic data were recorded with a motion analysis system. Both freezers and non-freezers showed an increased spatial variability of leg movements compared to controls. In addition, both patient groups had a deficit in interlimb coordination, not only between ipsilateral arms and legs, but also between diagonally positioned limbs. The only difference between freezers and non-freezers was a decreased step length during treadmill walking. We conclude that parkinsonian gait-regardless of FOG-is irregular, not only in the legs, but also with respect to interlimb coordination between the arms and legs. FOG is reflected by abnormal treadmill walking, presumably because this provides a greater challenge to the defective supraspinal control than overqround walking, hampering the ability of freezers to increase their stride length when necessary.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>France</li><li>Pays-Bas</li></country><region><li>Gueldre</li><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li><li>Province du Brabant flamand</li><li>Région flamande</li></region><settlement><li>Lille</li><li>Louvain</li><li>Nimègue</li></settlement><orgName><li>Katholieke Universiteit Leuven</li></orgName></list><tree><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Nanhoe Mahabier, W" sort="Nanhoe Mahabier, W" uniqKey="Nanhoe Mahabier W" first="W." last="Nanhoe-Mahabier">W. Nanhoe-Mahabier</name></region><name sortKey="Bloem, B R" sort="Bloem, B R" uniqKey="Bloem B" first="B. R." last="Bloem">B. R. Bloem</name><name sortKey="Delval, A" sort="Delval, A" uniqKey="Delval A" first="A." last="Delval">A. Delval</name><name sortKey="Overeem, S" sort="Overeem, S" uniqKey="Overeem S" first="S." last="Overeem">S. Overeem</name><name sortKey="Snijders, A H" sort="Snijders, A H" uniqKey="Snijders A" first="A. H." last="Snijders">A. H. Snijders</name><name sortKey="Weerdesteyn, V" sort="Weerdesteyn, V" uniqKey="Weerdesteyn V" first="V." last="Weerdesteyn">V. Weerdesteyn</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Delval, A" sort="Delval, A" uniqKey="Delval A" first="A." last="Delval">A. Delval</name></region></country><country name="Belgique"><region name="Région flamande"><name sortKey="Duysens, J" sort="Duysens, J" uniqKey="Duysens J" first="J." last="Duysens">J. Duysens</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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